"In 1976, the Federal Trade Commission ruled that these claims were misleading, and that Listerine had "no efficacy" at either preventing or alleviating the symptoms of sore throats and colds. Warner-Lambert was ordered to stop making the claims, and to include in the next $10.2 million worth of Listerine ads specific mention that "contrary to prior advertising, Listerine will not help prevent colds or sore throats or lessen their severity." -- Wikipedia.
If that sore throat is caused by a cold, then it has nothing to do with bacteria, since colds are caused by a virus. I am guessing Listerine wouldn't help - nor would penicillin, for that matter.
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